Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury
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چکیده
منابع مشابه
Leptin resistance protects mice from hyperoxia-induced acute lung injury.
RATIONALE Human data suggest that the incidence of acute lung injury is reduced in patients with type II diabetes mellitus. However, the mechanisms by which diabetes confers protection from lung injury are unknown. OBJECTIVES To determine whether leptin resistance, which is seen in humans with diabetes, protects mice from hyperoxic lung injury. METHODS Wild-type (leptin responsive) and db/d...
متن کاملThe cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis
BACKGROUND Arginine is an amino acid that serves as a substrate for the enzymes nitric oxide synthase (NOS) and arginase, leading to synthesis of NO and ornithine, respectively. As such, arginine has the potential to influence diverse fundamental processes in the lung. METHODS We used mice deficient in cationic amino acid transporter (CAT) 2 in models of allergic airway inflammation and pulmo...
متن کاملNLRP3 deletion protects from hyperoxia-induced acute lung injury.
Inspiration of a high concentration of oxygen, a therapy for acute lung injury (ALI), could unexpectedly lead to reactive oxygen species (ROS) production and hyperoxia-induced acute lung injury (HALI). Nucleotide-binding domain and leucine-rich repeat PYD-containing protein 3 (NLRP3) senses the ROS, triggering inflammasome activation and interleukin-1β (IL-1β) production and secretion. However,...
متن کاملDeletion of ASK1 Protects against Hyperoxia-Induced Acute Lung Injury
Apoptosis signal-regulating kinase 1 (ASK1), a member of the MAPK kinase kinase kinase (MAP3K) family, is activated by various stimuli, which include oxidative stress, endoplasmic reticulum (ER) stress, calcium influx, DNA damage-inducing agents and receptor-mediated signaling through tumor necrosis factor receptor (TNFR). Inspiration of a high concentration of oxygen is a palliative therapy wh...
متن کاملAsiaticoside attenuates hyperoxia-induced lung injury in vitro andin vivo
Objective(s): Asiaticoside (AS) displays anti-inflammation, and anti-apoptosis effect, but the role of AS in hyperoxia-induced lung injury (HILI) treatment is undefined. Therefore, the aim of this study was to investigate the effects of AS on HILI on premature rats and alveolar type II (AEC II) cells.Materials and Methods: Sprague-Dawley...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2019
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00223.2018